some virulence factors of staphylococci isolated from wound and skin infections in shahrekord, ir iran

conclusions: high percentage of hemolysins, biofilm and beta lactamase production by isolated staphylococci, suggests an important role of these virulence factors in the pathogenesis of isolated staphylococci from dermatitis lesions. the s. aureus isolates from wound infections, show a high sensitivity pattern to all examined antibiotics. only ciprofloxacin was found to be active against all isolates from dedermatitis lesions. objectives: the aim of the current study was based on the isolation and identification of staphylococcus aureus and coagulase negative staphylococci (cns) strains from various skin lesions and examining their biofilms, beta- lactamase, hemolysins production and antibiotic resistance pattern. materials and methods: sixty one infected wounds and 39 skin infections samples were collected and examined. after the culture and identification, examination for production of hemolysins, beta- lactamase, biofilm and susceptibility toward 9 antimicrobials was performed. results: out of 75 isolated staphylococci, sixty (80%) were biofilm producers. two overall prevalence of 28.5% and 100% of ß-lactamase production were recorded for isolated s. aureus and cns, respectively. twenty out of 49 (40.8%), the same number of α- and β- hemolytic s. aureus, were isolated while six (12.24%) were ∂ -hemolysin producers. twenty two of twenty six (84.6%) isolates of cns, were hemolysin producers that all were ∂ type. the s. aureus isolates from wound infections, show a high sensitivity pattern to all examined antibiotics, this sensitivity pattern for isolates from skin dermatitis is relatively low, though. background: staphylococci release a large number of enzymes. some of these, such as coagulase, beta- lactamase, hemolysins and biofilms are considered indices of pathogenicity.